KMID : 0384320150360060278
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Korean Journal of Family Medicine 2015 Volume.36 No. 6 p.278 ~ p.285
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Efficacy of Vitamin C Supplements in Prevention of Cancer: A Meta-Analysis of Randomized Controlled Trials
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Lee Bo-Bae
Oh Seung-Won Myung Seung-Kwon
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Abstract
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Background: Previous randomized controlled trials (RCTs) have reported inconsistent findings regarding the association between vitamin C supplementation and the risk of cancer.
Methods: We performed a meta-analysis of RCTs to investigate the efficacy of vitamin C supplements for prevention of cancer. We searched the PubMed, EMBASE, and Cochrane Library databases in November 2014 using common keywords related to vitamin C supplements and cancer.
Results: Among 785 articles, a total of seven trials were identified, which included 62,619 participants; 31,326 and 31,293 were randomized to vitamin C supplementation and control or placebo groups, respectively, which were included in the final analysis. A fixed-effects meta-analysis of all seven RCTs revealed no significant association between vitamin C supplementation and cancer (relative risk, 1.00; 95% confidence intervals, 0.95?1.05). Similarly, subgroup meta-analysis by dose of vitamin C administered singly or in combination with other supplements, follow- up period, methodological quality, cancer mortality, gender, smoking status, country, and type of cancer also showed no efficacy of vitamin C supplementation for cancer prevention.
Conclusion: This meta-analysis shows that there is no evidence to support the use of vitamin C supplements for prevention of cancer.
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KEYWORD
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Vitamin C, Ascorbic Acid, Cancer, Randomized Controlled Trials, Meta-Analysis
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